This time around, the homegrown motors will be electric-powered as the firm joins a Germany-wide race to produce affordable and high-performing climate-friendly cars.
Managers at Borgward have picked Bremen as the site for a new factory that will assemble vehicles from components - so-called "semi knocked-down" assembly - shipped over from its main factory in China.
Between the 1920s and 1960s, the northern port city was home to the firm's plant employing more than 20,000 workers.
After going bust in 1961, the marque lay dormant until being revived by Christian Borgward, grandson of the company founder, in 2015.
This time around, the inital job count will be much lower, at between 50 and 100 people.
A "flexible" factory with high levels of automation will "be able to increase output as well as the number of models to match demand," Borgward chief executive Ulrich Walker said in a statement.
And the finished product will be drastically different, with the German workers set to assemble BX7 all-electric sports utility vehicles (SUVs).
The modern, internet-connected vehicles will be a far cry from the stately coupes Borgward assembly lines turned out in the 1950s, which still count fans among classic car collectors.
Bremen's busy port of Bremerhaven, the availability of skilled labour, and high-quality parts suppliers all factored into Borgward's choice to return, CEO Walker said.
But he added that the firm was also "avowing itself to Germany as an industrial base and to our own origins."
The new site will allow Borgward to benefit from the coveted "Made in Germany" label - but bring with it much higher labour costs than in China.
According to German news agency DPA, it will be the first car factory built in Germany since BMW and Porsche opened works in Leipzig more than 10 years ago.
In Bremen, the revived Borgward will rub shoulders with a Mercedes-Benz factory employing 13,000 people.
The brand with the three-pointed star is a key protagonist in the car industry's race to conquer the electric automobile.
Dieter Zetschke, chief executive of Stuttgart-based Mercedes parent Daimler, has pledged to unveil 10 new electric cars in the coming years.
Meanwhile, just 200 kilometres (about 120 miles) down the road from Bremen is Wolfsburg, where Germany's most prolific carmaker Volkswagen is scrambling to recover from its "Dieselgate" emissions-cheating scandal by turning towards electric cars.
With yet more familiar German brands like BMW and Porsche also in the running, along with newcomers such as California's Tesla, Borgward is entering a crowded field.