Both upper Bavaria and Prague in the Czech Republic had unemployment rates of 2.5 percent last year, according to the study by Eurostat.
Southern German regions had some of the lowest unemployment rates in the entire European Union last year.
Nine of the ten regions with the lowest unemployment rates in the EU were within Germany.
Upper Bavaria was followed by Tübingen (2.6 percent) in the southwest, Oberpfalz (2.7) in the southeast and lower Bavaria (2.8).
Germany’s national unemployment rate was 5.0 percent - half of the EU average unemployment rate of 10.1 percent.
All of the ten regions with lowest youth unemployment rates could also be found in Germany, with upper Bavaria performing the best at 3.7 percent.
The five regions with the highest unemployment rates in the EU last year were all in Spain.
Swedish regions had the lowest rates of long-term unemployment, which refer to the number of unemployed people who have been out of work for more than a year.