"From a realistic point of view, the Bundesliga title has already been decided," the 24-year-old told Munich newspaper TZ with Bayern holding a 19-point lead at the top of the table.
"I don't think anyone is reckoning that we will lose six of our last remaining 12 matches when we haven't lost any of our 22 games up until now."
Müller is only stating what has been obvious for months, but it is the first time someone from the Bayern camp has admitted the title race is effectively decided.
Bayern have dropped just four points all season and are on course to repeat last season's treble of Champions League, Bundesliga and German Cup.
They host fourth-placed Schalke 04 at Munich's Allianz Arena on Saturday evening and, if Pep Guardiola's team maintain their huge lead, they will be crowned champions by March 29th at the latest.
Bayern are set to again break the league record for the earliest confirmed league title win having been crowned champions last season with six matches to spare.