Last season's treble winners have not yet lost in this campaign, winning 11 and drawing two matches in the Bundesliga while winning all five Champions
But ahead of Saturday's visit of Eintracht Braunschweig, Guardiola said they would be fighting a rearguard battle until Christmas.
"We're going to need to survive for two or three weeks," said the Catalan coach, who will lead his side to Morocco in a couple of weeks time for the
Club World Cup.
"But we have to make do, that's why we have a second team."
Captain Philipp Lahm is the latest addition to the treatment table with a hamstring injury, joining the likes of vice-captain Bastian Schweinsteiger, France winger Franck Ribery, Peru striker Claudio Pizarro, Switzerland wideman Xherdan Shaqiri and Germany defender Holger Badstuber.
Guardiola does at least have first choice Croatia forward Mario Mandzukic and full-back Diego Contento back for the clash with the Bundesliga's basement sitters, as the reigning champions seek to extend their record unbeaten run in the league to 39 matches.