The girl's parents returned from a trip from New York recently and have since been suffering with the virus. The couple's four-year-old daughter has not yet caught the bug.
In response to the girl's virus, the day care centre closed down on Thursday for almost two weeks, leaving the parents of the other 34 children looking for alternative care.
The three latest cases of swine flu are already recovering and not seriously ill.
There are now 17 known cases of swine flu in Germany, and the World Health Organisation reports there are more than 11,000 cases worldwide, resulting in 86 deaths. No one in Europe has died from the virus.