• Germany's news in English
 
Germans 'cut HIV out of infected cells'
Professor Buchholz at work. Photo: DPA

Germans 'cut HIV out of infected cells'

Published: 18 Dec 2013 14:05 GMT+01:00

Biomedicine researchers at Dresden's Technical University succeeded in curing several HIV-infected mice with the new method which uses an enzyme to cut the virus from the DNA of infected cells.

"There are various methods and similar approaches, but removing the virus from infected cells is unique," said Professor Joachim Hauber, head of the antiviral strategy section at partner research institute, Hamburg's Heinrich Pette Institute.

He said this approach was the only one so far which could actually reverse an HIV infection, leaving the treated cells healthy.

Whether this would function with people could only be established in clinical trials, he said, for which the money is not yet available.

Dresden team leader Professor Frank Buchholz said the 'molecular scissors' could be ready to use in ten years - as a somatic genetic therapy (using a patient's own gentically altered cells).

"Blood would be taken from patients and the stem cells which can form blood cells, removed," he said.

Laboratory work would introduce the crucial HIV-cutting enzyme into the stem cells, altering their DNA. They would then be put back into the patient.

The theory is that the genetically altered immune cells would reproduce, cut the HIV from infected cells - enabling them to function again.

This was the effect seen at least in part, among the mice.

"The amount of virus was clearly reduced, and even no longer to be found in the blood," said Hauber.

President of the German Aids Society, Professor Jürgen Rockstroh said he hoped funding could be found for further work on the approach.

"It is one of the most exciting things of all," he said. "There is a vague hope of cure, but that must first be proven."

The Dresden team have managed to create this enzyme - via mutation and selection - so that it identifies HIV.

"The HI-pathogen is a retrovirus which gets into the genetic substance in DNA," said Buchholz. Certain recombinase-class enzymes can cut up the DNA double helix and put it back together again in a different pattern.

The researchers have managed to manipulate the enzyme so that it can identify a particular sequence and remove it - and they say it is more than 90 percent effective in identifying the HI-virus in this way.

Hauber said the deciding phase, of bringing the approach to treating people in clinical studies, would be difficult in Germany.

"The potential is not being used," he said, claiming that pharmaceutical companies have until now shown little interest in investing in potential cures for Aids.

He and Buchholz said they would be looking for sponsors and public money for their future research.

READ MORE: Soldier infected two men with HIV

For more stories about Germany, join us on Facebook and Twitter

DPA/The Local (news@thelocal.de)

Your comments about this article

Today's headlines
'Hot Boy from Germany' wins Vietnam Idol
Image: Fremantle Media/YouTube

'Hot Boy from Germany' wins Vietnam Idol

A 22-year-old from Hanover has become the latest winner of Vietnam Idol – bagging $27,000 along with his new title. READ  

Man promises to stop coffin naps in public
If you want to rest in place while you're still alive, a car park isn't the place place to choose. Photo: DPA

Man promises to stop coffin naps in public

When a man walking his dog alerted police to the fact that a black coffin was lying in the middle of a public parking place, the cops were surprised to find someone inside. READ  

Court orders boss to pay worker for changing
Photo: Pixabay

Court orders boss to pay worker for changing

A mechanic from western Germany is set to receive €350 in back payments – after claiming he should be paid for the time he spent showering and getting dressed for work. READ  

In Pictures
Wacken festival draws metalheads of the world
A reveler at Wacken Open Air 2015. Photo: DPA

Wacken festival draws metalheads of the world

Armies of black-clad fans gathered for the world's biggest heavy metal festival between Thursday and Saturday, marking 25 years of headbanging fun in the small town of Wacken in northern Germany. READ  

Railway sunbather brings trains to a halt
Photo: DPA

Railway sunbather brings trains to a halt

A plucky sunbather brought train services in North Rhine-Westphalia to an abrupt halt at the weekend - after deciding to catch some rays on the tracks. READ  

Spiegel: Merkel wants fourth term in power
Angela Merkel. Photo: DPA

Spiegel: Merkel wants fourth term in power

According to Germany's most influential political magazine, Spiegel, Angela Merkel has decided to run for a fourth term in power and has already started talks on who will run her campaign. READ  

State leaders call for faster asylum processes
Refugees at a temporary reception centre in Baden Württemberg. Photo: DPA

State leaders call for faster asylum processes

Several state leaders called for more investment in processing asylum applications over the weekend as the backlog continues to put severe strain on current infrastructure. READ  

German sets Florida to Cuba speedboat record
Roger Klueh. Photo: Ernesto Mastrascusa / DPA

German sets Florida to Cuba speedboat record

A German businessman and power boating fanatic on Saturday broke a 57-year-old record for the fastest boat crossing between the United States and Cuba. READ  

Report: German refugee figures 'underestimated'
Migrants on a train on their way to the EU. Photo: Djordje Savic / DPA

Report: German refugee figures 'underestimated'

Germany has hosted more than 300,000 asylum seekers since the start of the year, said the daily Die Welt on Saturday, nearly 50,000 more than first thought, as Berlin prepares for a record influx of refugees in 2015. READ  

Migrant wounded in German police shooting
Photo: DPA

Migrant wounded in German police shooting

A Guinean migrant who caused a brawl in a home for asylum seekers in Germany was shot and seriously wounded by police, local media reported. READ  

RECEIVE OUR NEWSLETTER AND ALERTS
Business & Money
Start-up helps new Berliners short cut bureaucracy
National
The 1,000s of Germans massacred after the Second World War
Sport
Germany star scores own goal with PR gaffe
Features
'Women-only' parking: sensible or sexist?
Politics
Satire and reality blur in parody party's strife
National
13-year-old boy detained for trying to join Isis
Culture
Berlin restaurant serves up Greek Crisis Menu
Rhineland
Doctor on trial after woman wakes in morgue
Society
Six odd things Germans do in the summer
Sponsored Article
Outsourcing drives Apreel's Europe growth
Society
Police bust kinky Bavarian couple over painful love-making
Politics
Merkel brings Palestinian girl to tears
Hamburg
Amateur archaeologist finds Nazi gold hoard
National
Could Merkel learn a lesson in love from this doppelganger?
Travel
Why you should stay in Germany for the summer holidays
Sport
German press tell Schweinsteiger 'good riddance'
National
Hamburg gets a bouncing 100kg baby girl
Society
In North Germany, money sometimes DOES grow on trees
National
Hero mechanics stop Bavaria shooting spree
International
Denmark says that border controls are coming
National
Did hackers take control of German missile battery?
Politics
Munich gives gay pride green light
Business & Money
Berlin rent controls hit prices hard
National
Fighting to breastfeed in public without shame
Society
Ice cream for dogs 'gobbled up in one gulp'
Education
Are hotpants a feminist issue?
Rhineland
Lion cub reunited with mother
National
How the heatwave is cracking Germany's Autobahns
International
Why the French are more sympathetic to Greece than the Germans
Sponsored Article
Crans-Montana: International expat hub
Gallery
Police seize pensioner's WW2 heavy weapons haul
National
How to survive the Europe-wide heatwave
Sport
Is Schweini already out of the door at Bayern?
Politics
How German media shaped the Greece crisis
National
Car assembly robot crushes worker at Volkswagen
Rhineland
Weathermen red-faced over heatwave snow warning
Society
An eye for an eye? Mum protects child in playground with pepperspray
National
As it happened: Queen Elizabeth's final day in Germany
National
As it happened: Queen Elizabeth's second day in Germany
National
Queen Elizabeth II's first day in Germany - as it happened
National
Bus passengers tell fake racists where to get off
Latest news from The Local in Austria

More news from Austria at thelocal.at

Latest news from The Local in Switzerland

More news from Switzerland at thelocal.ch

Latest news from The Local in Denmark

More news from Denmark at thelocal.dk

Latest news from The Local in Spain

More news from Spain at thelocal.es

Latest news from The Local in France

More news from France at thelocal.fr

Latest news from The Local in Italy

More news from Italy at thelocal.it

Latest news from The Local in Norway

More news from Norway at thelocal.no

Latest news from The Local in Sweden

More news from Sweden at thelocal.se

7,129
jobs available
Toytown Germany
Germany's English-speaking crowd