• Germany's news in English
 

Germans 'cut HIV out of infected cells'

DPA/The Local · 18 Dec 2013, 14:05

Published: 18 Dec 2013 14:05 GMT+01:00

Biomedicine researchers at Dresden's Technical University succeeded in curing several HIV-infected mice with the new method which uses an enzyme to cut the virus from the DNA of infected cells.

"There are various methods and similar approaches, but removing the virus from infected cells is unique," said Professor Joachim Hauber, head of the antiviral strategy section at partner research institute, Hamburg's Heinrich Pette Institute.

He said this approach was the only one so far which could actually reverse an HIV infection, leaving the treated cells healthy.

Whether this would function with people could only be established in clinical trials, he said, for which the money is not yet available.

Dresden team leader Professor Frank Buchholz said the 'molecular scissors' could be ready to use in ten years - as a somatic genetic therapy (using a patient's own gentically altered cells).

"Blood would be taken from patients and the stem cells which can form blood cells, removed," he said.

Laboratory work would introduce the crucial HIV-cutting enzyme into the stem cells, altering their DNA. They would then be put back into the patient.

The theory is that the genetically altered immune cells would reproduce, cut the HIV from infected cells - enabling them to function again.

This was the effect seen at least in part, among the mice.

"The amount of virus was clearly reduced, and even no longer to be found in the blood," said Hauber.

President of the German Aids Society, Professor Jürgen Rockstroh said he hoped funding could be found for further work on the approach.

"It is one of the most exciting things of all," he said. "There is a vague hope of cure, but that must first be proven."

The Dresden team have managed to create this enzyme - via mutation and selection - so that it identifies HIV.

"The HI-pathogen is a retrovirus which gets into the genetic substance in DNA," said Buchholz. Certain recombinase-class enzymes can cut up the DNA double helix and put it back together again in a different pattern.

The researchers have managed to manipulate the enzyme so that it can identify a particular sequence and remove it - and they say it is more than 90 percent effective in identifying the HI-virus in this way.

Hauber said the deciding phase, of bringing the approach to treating people in clinical studies, would be difficult in Germany.

"The potential is not being used," he said, claiming that pharmaceutical companies have until now shown little interest in investing in potential cures for Aids.

He and Buchholz said they would be looking for sponsors and public money for their future research.

READ MORE: Soldier infected two men with HIV

For more news from Germany, join us on Facebook and Twitter.

DPA/The Local (news@thelocal.de)

Your comments about this article

Today's headlines
Robber threatens woman with “HIV syringe”
File photo: DPA

Robber threatens woman with “HIV syringe”

1 hour ago

A shocked woman in Munich called police on Sunday evening after a man climbed into her car, demanded her purse – and threatened her with a syringe he said contained HIV.

Day in court for first Loveparade tragedy case
Crosses adorn the stairs which festival-goers fought to reach to escape the crush. Photo: DPA

Day in court for first Loveparade tragedy case

2 hours ago

July 2015 marked five years since one of the worst tragedies in modern German history. But this week, those affected by the 2010 Duisburg Loveparade disaster will at last see the case come to court.

Refugee crisis tests EU's core ideals: Merkel
Angela Merkel. Photo: DPA

Refugee crisis tests EU's core ideals: Merkel

2 hours ago

German Chancellor Angela Merkel on Monday said the refugee crisis facing Europe is testing the core ideals of universal rights at the heart of the European Union.

German named 'arse bombing' world champ
Going down with a bang. The splash diving championships 2015. Photo: DPA

German named 'arse bombing' world champ

5 hours ago

Summer went out with a bang - and a splash - in southwest Germany, where the finals of the "arse bombing“ world championship 2015 were held on Sunday.

Formula One
Rosberg 'overwhelmed' by birth of daughter
Formula One Mercedes driver Nico Rosberg with his wife Vivian. File photo: DPA

Rosberg 'overwhelmed' by birth of daughter

6 hours ago

Star Formula One driver Nico Rosberg confirmed on Monday that he and his wife Vivian are now the parents of a baby girl, saying the couple were “overwhelmed and totally in love”.

'No limit to refugees Germany can take in'
Refugees arrive at an intake centre. Photo: DPA

'No limit to refugees Germany can take in'

7 hours ago

Germany's top official dealing with refugees said on Monday that there was 'no upper limit' to Germany's capacity for taking in people in need of asylum.

Berlin orchestra's Tehran concert blocked by Iran
Daniel Barenboim. Photo: DPA

Berlin orchestra's Tehran concert blocked by Iran

9 hours ago

Iran has barred famed conductor Daniel Barenboim from entering the Islamic republic because of his Israeli citizenship, thwarting his plan to lead a performance in Tehran, media reported Sunday.

Bundesliga
Dortmund reclaim top spot with Hertha win
Borussia Dortmund celebrate scoring against Hertha Berlin. Photo:DPA

Dortmund reclaim top spot with Hertha win

9 hours ago

Borussia Dortmund reclaimed top spot in the Bundesliga from Bayern Munich on Sunday with a 3-1 victory over Hertha Berlin -- their eighth straight win under new coach Thomas Tuchel.

Germany's friendship vow to Afghanistan
Frank-Walter Steinmeier in Afghanistan on Sunday. Photo:DPA

Germany's friendship vow to Afghanistan

9 hours ago

Foreign Minister Frank-Walter Steinmeier said that German friendship with Afghanistan had "no end date" as he visited Kabul under tight security on Sunday.

Migrants crisis
German media and celebs rally for refugees
A welcome party for refugees in Heidenau on Friday. Photo: DPA

German media and celebs rally for refugees

1 day ago

Germany may have witnessed violent anti-refugee protests this week -- but the message from the country's media and celebrities is a loud and determined welcome for people fleeing the horrors of war.

RECEIVE OUR NEWSLETTER AND ALERTS

National
Weekend of anti-refugee violence shocks Germany
National
Half of Germans 'have had sex in their car'
Society
Deadly stew spooks home vegetable gardeners
Politics
The man who brought two Germanies together
Features
Where to get your culture fix in Cologne
Education
Fairytale world of Brothers Grimm brought to life
Rhineland
Thieves leave 1,000 open beers untasted
National
Way to some Germans' hearts is through their wallets
National
Germany's biggest challenge: European refugee crisis
Travel
Where to get your adrenaline pumping in Germany
Technology
Could thieves hack into luxury cars?
What to watch out for when snapping your lunch
National
German lefties through history
National
The fight over prostitution heats up
National
Merkel: migrants, not Greece, are the real challenge
Features
How I explained the Queen to the Germans
Education
Why Germany does 'back-to-school' traditions better
National
Germans are ‘not how foreigners think’
National
A mum and daughter reunite 70 years after WWII
Sport
Bra stops bullet in hunting mishap miracle
National
Cows trample German woman to death in Graubünden Alps
Business & Money
Start-up helps new Berliners short cut bureaucracy
National
The 1,000s of Germans massacred after the Second World War
Sport
Germany star scores own goal with PR gaffe
Features
'Women-only' parking: sensible or sexist?
Politics
Satire and reality blur in parody party's strife
National
13-year-old boy detained for trying to join Isis
Culture
Berlin restaurant serves up Greek Crisis Menu
Rhineland
Doctor on trial after woman wakes in morgue
Society
Six odd things Germans do in the summer
Society
Police bust kinky Bavarian couple over painful love-making
Politics
Merkel brings Palestinian girl to tears
Hamburg
Amateur archaeologist finds Nazi gold hoard
National
Could Merkel learn a lesson in love from this doppelganger?
Travel
Why you should stay in Germany for the summer holidays
Sport
German press tell Schweinsteiger 'good riddance'
National
Hamburg gets a bouncing 100kg baby girl
Latest news from The Local in Austria

More news from Austria at thelocal.at

Latest news from The Local in Switzerland

More news from Switzerland at thelocal.ch

Latest news from The Local in Denmark

More news from Denmark at thelocal.dk

Latest news from The Local in Spain

More news from Spain at thelocal.es

Latest news from The Local in France

More news from France at thelocal.fr

Latest news from The Local in Italy

More news from Italy at thelocal.it

Latest news from The Local in Norway

More news from Norway at thelocal.no

Latest news from The Local in Sweden

More news from Sweden at thelocal.se

6,967
jobs available
Toytown Germany
Germany's English-speaking crowd