The cuts are part of a general restructuring of the group's businesses in plastic additives, pigments, water, leather and textile chemicals in response to "the changed market environment," BASF said in a statement.
"The currently planned measures will lead to a reduction of about 500 positions worldwide by the end of 2015."
In Basel in particular, centre of BASF's European operations for the plastic additives, pigments and resins business, a total 350 jobs would be cut by the end of 2015, the statement said.
The group pledged to implement the cuts "in a socially responsible manner."
BASF "will attempt to find job opportunities in other BASF Group companies for as many employees as possible," it said.