Police said they would turn out in force and strictly monitor compliance with mask-wearing and social distancing, with Berlin police chief Barbara Slowik warning that if the demonstrators do not adhere to virus safety rules, police will clear the area “very quickly”.
“We will not be able or willing to watch tens of thousands assemble and create infection risks,” she added.
Berlin city authorities had previously decided not to allow the Saturday demonstration to go ahead, fearing that the estimated 22,000 protesters would not keep a distance of 1.5 metres apart or comply with face mask requirements.
The ban sparked outrage from organisers and their supporters who flooded social media with angry messages vowing to protest anyway, with some even calling for violence.
But on the eve of the demo, Berlin's administrative court sided with the demonstrators, saying there was no indication that organisers would “deliberately ignore” social distancing rules and endanger public health.
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A crowd including families with children gathered Saturday morning around Brandenburg Gate, the starting point of the demonstration.
“I'm not an extreme right-wing sympathiser, I'm here to defend our fundamental freedoms,” said Stefan, a 43-year-old Berlin resident with a shaved head and a T-shirt with the words “Thinking helps” written in large print.
“We're here to say: we have to be careful! Coronavirus crisis or not, we must defend our freedoms,” Christina Holz, a 22-year-old student, told AFP.
Around 3,000 police officers, including 1,000 federal police, will be deployed for the demonstration, alongside specialist equipment including water cannon, Slowik said.
The rally comes as coronavirus cases continue to rise in Germany, with daily new infection numbers reaching highs not seen since April.
At a press conference on Friday, Chancellor Angel Merkel said confronting the virus will become more challenging in the coming autumn and winter months.
Merkel and the leaders of Germany's 16 federal states on Thursday introduced tougher coronavirus restrictions to curb the pandemic, including a minimum 50 euro ($59) fine for people caught not wearing face masks where one
“We will have to live with this virus for a long time to come. It is still serious. Please continue to take it seriously,” Merkel warned.
The court decision to allow the protest shines a light on the battle lines being drawn up between those who are content to follow government-mandated protection measures and those who believe that governments shouldn't be able to dictate how people live.
At the start of August, a similar “anti-corona” march in Berlin took place with 20,000 protesters, a mixture of the hard left and right, anti-vaccination campaigners, conspiracy theorists and self-described “free thinkers”.
Police broke up the protest early after participants repeatedly flouted Covid-19 safety regulations.
The far-right welcomed Friday's court ruling allowing the latest demo to go ahead, with Leif-Erik Holm, a lawmaker for the anti-migrant AfD party, calling it “a victory for freedom”.
But several groups intend to stage counter-demonstrations to the main protest.
Anne Helm from the left-wing party Die Linke and an MP in Berlin's parliament, said: “There must be no tolerance towards racists, anti-Semites, right-wing extremists and Nazis. That is why I call on all Berliners to take part in the counter-events.”
Meanwhile, the German Hotel and Restaurant Association reported that hotels in the capital recorded noticeably more bookings for the weekend.
“We assume that the rooms were booked in connection with the demonstration,” Thomas Lengfelder, the association's local leader, told the Augsburger Allgemeine newspaper.
Several countries around the world have seen protests against coronavirus restrictions and lockdown measures in recent months.