The 250 kilogramme bomb was found in Nuthepark a week ago on Tuesday and is to be defused later in the day once the evacuation is complete, the Berliner Morgenpost reports.
Most of the city centre had been evacuated by 10am on this Tuesday morning. The central train station had been closed down with no trains arriving at or departing the station.
Businesses and apartments were also slowly being emptied out, as officials from the Ordnungsamt went door to door to ensure that everyone had left the area.
An area within an 800-metre circumference of the bomb was shut down. The affected area includes the entire south of the city centre and the area around the Altmarkt.
All residents were expected to have left the area by 7.30 am and the defusal was set to take place before noon. The city has stated that, if everything goes according to plan, the evacuation will be over in the early afternoon.