The strikes are affecting Bavaria, Hesse, Baden-Württemberg and Saxony.
Focus reports that over 400 kindergartens in Bavaria alone have been affected by the strikes.
The walk-outs follow on from Tuesday's strikes in Hamburg and Lower Saxony.
Ver.di called the strikes in the build up to the next round of negotiations on pre-school teachers' salaries, set to be held on Thursday in Düsseldorf.
The trade union is demanding that the pre-school teachers be put in a higher pay grade, meaning they would stand to earn several hundred Euros more per month.
According to the Hannoversche Allgemeine Zeitung the strikes will not go away any time soon.
“In the current negotiations the weakest links in a long chain are meeting with one another: The representatives of the pre-school teachers with the representatives of the state and local councils. This doesn't indicate a quick resolution, but rather long strikes.”