The world premiere of "Nobody Wants the Night" on February 5 will kick off the 11-day festival known as the Berlinale.
"The adventure film focuses on courageous women and ambitious men who put anything at stake for love and glory," festival organisers said.
As well as the Oscar-winning Binoche, the cast includes Japanese actress Rinko Kikuchi, who was nominated for an Academy Award for her role as a mute, deaf teenager in Alejandro Gonzalez Inarritu's 2006 hit "Babel", and Irish actor Gabriel Byrne.
"I'm very pleased that 'Nobody Wants the Night' will open the 2015 Berlinale," festival director Dieter Kosslick said about the film that will also be a contender in the festival's international competition.
"Isabel Coixet has created an impressive and perceptive portrait of two women in extreme circumstances."
Coixet has been a regular face at the Berlinale in recent years, with six films shown in past festivals. She was also a jury member in 2009.
In 2013, her movie "Ayer No Termina Nunca" (Yesterday Never Ends), set in Spain in 2017 about the impact of Europe's financial crisis, also held its world premiere at the Berlin festival.
New movies by Terrence Malick, Kenneth Branagh and Peter Greenaway are also set to screen during the February 5-15 festival, the year's first major European cinema showcase.
US director and screenwriter Darren Aronofsky will serve as president of the jury handing out the Golden and Silver Bear prizes.