Emergency services were still at the scene of the gas pipe blast - a building site in Ludgwigshafen - on Friday and are expected to remain there for several hours with a cordon still in place.
The area is still sealed off as the fire service discovered a fresh leak from a gas pipe, a police spokesman said on Friday morning.
People living within a 150-metre radius of the building site have been asked to leave their homes and keep doors and windows closed.
Some have had little choice but to leave, as around 50 homes were damaged in the original blast.
GALLERY: Explosion rocks Ludwigshafen
The gas pipe exploded in the Oppau area of Ludwigshafen on Thursday at 11.30am.
A construction worker died and four others were seriously injured. A total of 26 people were hurt.
The construction crew had been called to a fix a problem with the high-pressure gas pipe several days previously.
A huge crater around six metres deep and 10 metres wide opened up at the site.
Police and prosecutors are now investigating the blast.