Speaking in the old town square of Seligenstadt near Frankfurt late Wednesday, the woman affectionately dubbed "Mutti" or mum by some made the case that her conservative government is the most successful since reunification in 1990.
Undeterred by some hecklers, she pointed at achievements in health, education and elderly care as she kicked off a whirlwind campaign tour that will see her speak at 56 events in 40 days.
In the enthusiastic crowd of around 1,000 supporters, many waved placards reading "Angie".
"Her speech was extraordinary," gushed one supporter, economics student Christoph Koser, 24. "She manages to engage us in her party because in her programme there is something for everyone."
Merkel, despised in parts of crisis-hit Europe for insisting on tough austerity, is popular in Germany where many see her as a responsible guardian of the public purse.
Pushing her message of fiscal discipline, Merkel told the crowd: "We have seen in Europe what happens when debts are too high. Growth on borrowed money – that's impossible."
The launch ahead of the September 22nd vote came as data released on Wednesday morning showed the German economy grew 0.7 percent in the second quarter of 2013, helping to propel the eurozone out of its stubborn recession
To many observers, calm and pragmatic Merkel, Forbes magazine's most powerful woman in the world, seems an immovable force, and few can imagine she will not stay in power.
"She has become something like the mother of the nation, in quotation marks," said political scientist Oskar Niedermayer of Berlin's Free University. He described her as “carer-in-chief.”
Niedermayer added that in Germany, where the unemployment rate is 6.8 percent, the eurozone crisis seemed like an abstract threat to many, and that "the citizens believe she has steered Germany through the crisis."
"She is also staying out of intra- and inter-party battles and quarrels,” he added. "She has a rather presidential leadership style. She seems unflappable and sober, and the people like that."
Merkel's personal popularity lead over her main challenger Peer Steinbrück of the Social Democratic Party (SPD) has narrowed a few points but remains at a commanding 54-23 percent, the latest Forsa institute survey found.
"It will be an extremely personalised campaign ... highly focused on the chancellor," said Martin Koopmann of the Genshagen Foundation think-tank. "Merkel has created a situation in the party where there are very few other high-profile people."
The Forsa poll also gave Merkel's Christian Democrats (CDU) and its Bavarian sister party a 40-23 percent lead over the SPD, and 13 percent for the Social Democrats' campaign ally the Greens.
This would mean that Merkel's party, together with its junior partner the pro-business Free Democrats (FDP), which scored five percent, would have a narrow governing majority.
However, if the FDP drops below five percent, it would fail to enter parliament. Such a result would force Merkel to seek new allies – either the Greens, seen as a long shot, or the SPD, with whom she previously ruled in a 'grand coalition' in her first term.
Merkel, 59, has already adopted many centre-left policies, on issues from renewable energy to gay marriage, to gain the political centre, depriving her rivals of issues to attack her on.
Steinbrück, 66, has so far had a difficult campaign, hobbled by gaffes. This week he apologised for saying Merkel's upbringing in communist East Germany made her a less enthusiastic European, comments that offended voters in eastern states.