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Pesticides can trigger Parkinson's disease

The Local · 4 Dec 2012, 14:44

Published: 04 Dec 2012 14:44 GMT+01:00

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Publishing their findings in the journal "Nature Scientific Reports," the scientists showed how the poison rotenone caused and exacerbated Parkinson's.

The disease causes deterioration of a person's central nervous system, which results in rigid muscles, a mask-like facial expression and uncontrollable shaking. Primarily affecting the elderly, Parkinson's symptoms occur when the brain's nerve cells producing the neurotransmitter dopamine die.

Although it has long been suspected that external factors could cause Parkinson's, the latest research shows that agricultural workers frequently exposed to pesticides develop the disease more often than people with less experience of the chemicals.

The scientists also discovered that rotenone given to mice produced a protein in their intestinal tract that destroyed brain cells.

"If this can also be confirmed in Parkinson's patients, we will have taken an important step towards new strategies for diagnose and treatment," said Francisco Pan-Montojo, the director of the Dresden Institute for Anatomy.

Story continues below…

DAPD/The Local/mry

The Local (news@thelocal.de)

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Your comments about this article

18:12 December 4, 2012 by rolfdegen
Interestingly, the pesticide, which is suspected of causing Parkinson, is rotenone. It is a plant extract and is disseminated practical only for organic farmers. In Germany it is prohibited, but on organic vegetables from abroad (including EU and Switzerland) it is often detectable.
20:02 December 5, 2012 by robiniawood
It's not only Rotenone that raises the risk for Parkinson's, but other pesticides too, scientists show

"They found that the combined exposure to ziram, maneb and paraquat near any workplace increased the risk of Parkinson's disease (PD) threefold, while combined exposure to ziram and paraquat alone was associated with an 80 percent increase in risk. The results appear in the current online edition of the European Journal of Epidemiology."

09:45 December 6, 2012 by rolfdegen
The study you cite contains only epidemiological data; it can not establish causality but only correlation. You have to do experiments to prove a causal connection. And this has been hard to do so far. Earlier experiments on Rotenone and Parkinson by Mona Thiruchelvam later turned out to be fabrications, you can google this.
01:55 December 24, 2012 by cleansemart
Vitamin K2 & Parkinson disease, research was done in collaboration with colleagues from Northern Illinois University (US) and was recently published in the journal Science.

"It appears from our research that administering vitamin K2 could possibly help patients with Parkinson's. However, more work needs to be done to understand this better," says Patrik Verstreken.

Malfunctioning power plants are at the basis of Parkinson's.


If we looked at cells as small factories, then mitochondria would be the power plants responsible for supplying the energy for their operation. They generate this energy by transporting electrons. In Parkinson's patients, the activity of mitochondria and the transport of electrons have been disrupted, resulting in the mitochondria no longer producing sufficient energy for the cell. www.cleansemart.com This has major consequences as the cells in certain parts of the brain will start dying off, disrupting communication between neurons. The results are the typical symptoms of Parkinson's: lack of movement (akinesia), tremors and muscle stiffness.
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