In the southern state of Baden-Württemberg, a bakery delivery truck spun out of control and hit a snowplough head-on, severely injuring the driver.
A 71-year-old pedestrian in the neighbouring state of Bavaria was hit by a sliding van in Hof, suffering life-threatening head injuries. Police said the driver of the vehicle was unable to stop in time due to treacherous road conditions.
Meanwhile on the A71 motorway in Bavaria, police reported six auto accidents involving a total of 20 vehicles along a stretch of road just a few hundred metres long. Twelve people were injured, with five hospitalized, among them a five-year-old child.
Winter weather also caused an accident between a train and a tractor trailer truck in Bavaria's Upper Palatinate region. The collision injured the train driver and one of his 30 passengers, along with the truck driver.
In the central German state of Saxony, police reported an accident along the A72 where a car rolled after hitting another vehicle, then landed on another. The 24-year-old driver sustained severe injuries, they said.
In Hesse, a 35-year-old driver was also severely injured when he lost control of his car and landed in a ditch, hitting a drain pipe.
Police estimated that accidents had caused hundreds of thousands of euros in damage by mid-morning.
A cold front blowing over Germany from Ireland is expected to bring chilly temperatures and snow to southern and eastern Germany in the coming days. Areas above between 200 and 400 metres in altitude should expect “light to moderate” accumulation and slippery road conditions, DWD meteorologist Thomas Ruppert said.
High temperatures for Wednesday will range between 0 and 4 degrees Celsius, with scattered snow showers set to continue overnight as temperatures drop to between -2 and -9 degrees.
Eastern Germany and southern mid-range mountains will see more snow on Thursday, which will be slightly colder at between -2 and 2 degrees.
Snowflakes are likely to fall again on Friday when chilly temperatures will prevail, dropping as low as -15 overnight.
But by Saturday conditions are likely to improve, Ruppert said, with just a few snowflakes and partly cloudy conditions.