Ryanair plans to reduce its capacity in the German capital by 56 percent, scrapping flights to four cities from the Berlin-Schönefeld airport from mid-2011, the firm said in a statement.
Three domestic lines will be cut along with one to the Lithuanian city of Kaunas. Service from Bremen and a regional airport outside Düsseldorf will also be reduced.
The Irish airline announced other cuts in October and blames an airline tax approved by the German government which would cost between €8 and €45 depending on the length of the flight.
The tax is part of an austerity plan established in Berlin and is expected to raise around €1 billion per year.
Overall capacity in Germany is expected to fall by three million passengers per year and lead to the elimination of 3,000 jobs, the carrier said.